BindingDB BDBM35229 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine::5-(gamma-methylaminopropyl)iminodibenzyl::CHEMBL72::DESIPRAMINE HYDROCHLORIDE::DMI::Desipramin::Desipramine::Desmethylimipramine::N-(3-methylaminopropyl)iminobibenzyl::US9944618, Compound ID No. 174::demethylimipramine::monodemethylimipramine::norimipramine

BDBM35229 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine::5-(gamma-methylaminopropyl)iminodibenzyl::CHEMBL72::DESIPRAMINE HYDROCHLORIDE::DMI::Desipramin::Desipramine::Desmethylimipramine::N-(3-methylaminopropyl)iminobibenzyl::US9944618, Compound ID No. 174::demethylimipramine::monodemethylimipramine::norimipramine

SMILES CNCCCN1c2ccccc2CCc2ccccc12

InChI Key InChIKey=HCYAFALTSJYZDH-UHFFFAOYSA-N

Data 127 KI 58 IC50 2 Kd

PDB links: 6 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 35229

Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wyeth Laboratories

Curated by PDSP K_i Database

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

Ki: 20nMMore data for this Ligand-Target Pair

Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wyeth Laboratories

Curated by PDSP K_i Database

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

Ki: 353nMMore data for this Ligand-Target Pair

Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wyeth Laboratories

Curated by PDSP K_i Database

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

Ki: 1.00E+3nMMore data for this Ligand-Target Pair

Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

Ki: 3.00E+3nMAssay Description:Compound was tested for inhibition of [3H]-WIN- 35,428 binding to thehuman (DAT) dopamine transporterMore data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wyeth Laboratories

Curated by PDSP K_i Database

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

Ki: 3.03E+3nMMore data for this Ligand-Target Pair

Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

Ki: 3.19E+3nMMore data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wyeth Laboratories

Curated by PDSP K_i Database

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

Ki: >4.00E+3nMAssay Description:Inhibitory constant towards reuptake of [125I]-12 from dopamine transporter in rat striatal membranesMore data for this Ligand-Target Pair

Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

Ki: 4.57E+3nMAssay Description:DAT: This protocol was designed to measure inhibition of uptake by the human dopamine transporter. The reagents were human DAT (HEK293F) cells, GBR 1...More data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wyeth Laboratories

Curated by PDSP K_i Database

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

Ki: 5.95E+3nMMore data for this Ligand-Target Pair

Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wyeth Laboratories

Curated by PDSP K_i Database

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

Ki: 6.53E+3nMAssay Description:Inhibition of the uptake of tritiated dopamine (DA) in rat synaptosomesMore data for this Ligand-Target Pair

Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wyeth Laboratories

Curated by PDSP K_i Database

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

Ki: 6.53E+3nMAssay Description:Inhibition of dopamine (DA) uptake into rat brain synaptosomesMore data for this Ligand-Target Pair

Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wyeth Laboratories

Curated by PDSP K_i Database

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

Ki: >1.00E+4nMAssay Description:Ability to inhibit reuptake of dopamine ([3H]DA) at dopamine transporter of rat striatumMore data for this Ligand-Target Pair

Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wyeth Laboratories

Curated by PDSP K_i Database

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

Ki: >1.00E+4nMAssay Description:Inhibitory constant against reuptake of [3H]-DA at dopamine transporter of rat striatal membranesMore data for this Ligand-Target Pair

Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wyeth Laboratories

Curated by PDSP K_i Database

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wyeth Laboratories

Curated by PDSP K_i Database

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wyeth Laboratories

Curated by PDSP K_i Database

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Wyeth Laboratories

Curated by PDSP K_i Database

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

IC50: 4.79E+4nMAssay Description:Inhibition of [3H]dopamine uptake in human wild type DAT transfected HEK293 cellsMore data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL

PNG

BDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)

IC50: 8.20E+4nMAssay Description:Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
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Filter my 187 hits

Targets 40▿
- Sodium-dependent noradrenaline transporter 43
- Sodium-dependent serotonin transporter 27
- Sodium-dependent dopamine transporter 21
- Norepinephrine transporter 10
- Transporter 8
- Histamine H1 receptor 7
- Potassium voltage-gated channel subfamily H member 2 7
- Muscarinic acetylcholine receptor M2 6
- Solute carrier family 22 member 1 5
- Alpha-1A adrenergic receptor 5
- 5-hydroxytryptamine receptor 2A 4
- 5-hydroxytryptamine receptor 2C 3
- 5-hydroxytryptamine receptor 1A 3
- Voltage-dependent L-type calcium channel subunit alpha-1C 3
- Bile salt export pump 3
- Solute carrier family 22 member 2 2
- Alpha-2C adrenergic receptor 2
- Solute carrier family 22 member 3 2
- Histamine H3 receptor 2
- D(2) dopamine receptor 2
- 5-hydroxytryptamine receptor 7 2
- Alpha-2A adrenergic receptor 2
- Solute carrier family 22 member 4 1
- Sigma non-opioid intracellular receptor 1 1
- Voltage-dependent N-type calcium channel subunit alpha-1B 1
- Albumin 1
- Muscarinic acetylcholine receptor M5 1
- Muscarinic acetylcholine receptor M4 1
- Muscarinic acetylcholine receptor M3 1
- Cytochrome P450 2J2 1
- Muscarinic acetylcholine receptor M1 1
- Sodium channel protein type 5 subunit alpha 1
- Beta-2 adrenergic receptor 1
- ATP-binding cassette sub-family C member 3 1
- ATP-binding cassette sub-family C member 4 1
- ATP-binding cassette sub-family C member 2 1
- 5-hydroxytryptamine receptor 3A 1
- D(1A) dopamine receptor 1
- Sodium channel protein type 1/2/3 subunit alpha 1
- Histamine H2 receptor 1
- ...
Publications 50▿
- J Pharmacol Exp Ther 283: 1305-22 (1997) 12
- Biochem Pharmacol 35: 4493-7 (1986) 8
- Psychopharmacology (Berl) 114: 559-65 (1994) 7
- NIDA Res Monogr 178: 440-66 (1998) 6
- Biochem Pharmacol 45: 2352-4 (1993) 5
- J Med Chem 53: 7869-73 (2010) 5
- J Pharmacol Exp Ther 226: 686-700 (1983) 4
- US Patent US9944618 (2018) 4
- Toxicol Sci 136: 216-41 (2013) 4
- J Med Chem 27: 943-6 (1984) 3
- Bioorg Med Chem Lett 15: 2461-5 (2005) 3
- Antimicrob Agents Chemother 51: 4133-40 (2007) 3
- Psychopharmacology (Berl) 126: 234-40 (1996) 3
- Eur J Pharmacol 340: 249-58 (1997) 3
- J Pharmacol Exp Ther 301: 1097-102 (2002) 3
- Synapse 39: 32-41 (2001) 3
- Neuropharmacology 45: 935-44 (2003) 3
- Bioorg Med Chem Lett 13: 3565-9 (2003) 3
- J Pharmacol Exp Ther 293: 686-96 (2000) 3
- J Med Chem 42: 3154-62 (1999) 3
- J Pharmacol Exp Ther 290: 761-7 (1999) 3
- J Med Chem 33: 2899-905 (1990) 3
- J Pharmacol Exp Ther 318: 657-65 (2006) 3
- Neuropsychopharmacology 27: 699-711 (2002) 3
- J Med Chem 30: 1433-54 (1987) 3
- J Pharmacol Exp Ther 222: 61-5 (1982) 3
- Cardiovasc Res 91: 53-61 (2011) 3
- Neuropharmacology 27: 399-408 (1988) 2
- Neuropharmacology 32: 737-43 (1993) 2
- Science 317: 1390-3 (2007) 2
- J Med Chem 53: 2051-62 (2010) 2
- J Med Chem 59: 6329-43 (2016) 2
- J Med Chem 24: 1499-507 (1982) 2
- J Med Chem 53: 4511-21 (2010) 2
- J Med Chem 51: 4038-49 (2008) 2
- J Med Chem 21: 78-82 (1978) 2
- J Biol Chem 268: 18200-4 (1993) 2
- J Appl Toxicol 32: 858-66 (2012) 2
- J Med Chem 52: 5703-11 (2009) 2
- J Med Chem 54: 6824-31 (2011) 2
- Am J Physiol Renal Physiol 281: 454-68 (2001) 2
- Bioorg Med Chem 51: (2021) 1
- Bioorg Med Chem Lett 19: 2464-7 (2009) 1
- J Med Chem 42: 2721-36 (1999) 1
- Bioorg Med Chem Lett 20: 2809-12 (2010) 1
- J Nat Prod 69: 1305-9 (2006) 1
- DNA Cell Biol 16: 871-81 (1997) 1
- Synapse 32: 198-211 (1999) 1
- Proc Natl Acad Sci U S A 75: 6290-4 (1978) 1
- Bioorg Med Chem Lett 11: 655-8 (2001) 1
- ...
Institutions 35▿
- Emory University 12
- TBA 11
- Wyeth Research 11
- Mayo Clinic 10
- Eli Lilly 9
- Mayo Foundation 9
- Pfizer 8
- Wyeth Laboratories 8
- Sri International 6
- Abbott Laboratories 5
- Amgen 4
- Universidad De Valencia 3
- The University of Queensland 3
- Wake Forest University 3
- Wyeth-Ayerst Research 3
- Veterans Affairs Medical Center 3
- Acenta Discovery 3
- University of Turku 3
- Georgetown University Medical Center 3
- University Of Oxford 3
- Harvard University 3
- Nih 3
- National Institute of Neurological Disorders and Stroke 2
- Institute Of Anatomy Of The Bayerische Julius-Maximilians-Universit£T 2
- Organon International 2
- Jagiellonian University 2
- East China Normal University 2
- Boots Pharmaceuticals 2
- New York University School Of Medicine 2
- University Of The Punjab 1
- Virginia Commonwealth University 1
- Research Triangle Institute 1
- Medical And Pharmaceutical Industry Technology And Development Center 1
- Anatomisches Institut Der Bayerischen Julius-Maximilians-Universit£T 1
- Mcgill University 1
- ...
Affinity: 0.060 to 8.5E+5 nM▿
- Ki 127
- IC50 58
- Kd 2
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1